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67(19):9472-81
ITD-1 was used at 5 µM final concentration in vitro and in cellular assays
-20oC for 6 month
Trans-ISRIB displayed a half-life in plasma of 8 hr and readily crossed the blood-brain barrier
and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice
COMPOUND 401 - CAS# 168425-64-7 033 67(19):9472-81Compound 401, CAS No. 168425 64 7, is a potent and selective inhibitor of DNA dependent protein kinase (DNA PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0. 28 and 5. 3 M respectively). Product information CAS Number: 168425 64 7 Molecular Weight: 281. 31 Formula: C16H15N3O2 Synonym: Compound 401 Compound 401 Compound401 Chemical Name: 2 (4 Morpholinyl) 4H pyrimido[2,1 a]isoquinolin 4 one Smiles: O=C1C=C(N=C2C3=CC=CC=C3C=CN21)N1CCOCC1
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